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    Antioxidant lignans from Larrea tridentata
    (2004) Abou-Gazar H.; Bedir E.; Takamatsu S.; Ferreira D.; Khan I.A.
    Three lignans, (7S,8S,7'S,8'S)-3,3',4'-trihydroxy- 4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8S,7'S,8'S)-3,4, 3',4'-tetrahydroxy-7,7'-epoxylignan with significant antioxidant properties, and (E)-4,4'-dihydroxy-7,7'-dioxolign- 8(8')-ene, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR analysis. Their antioxidant activities were evaluated on intracellular reactive oxygen species in HL-60 cells. Three lignans, (7S,8S,7'S,8'S)-3, 3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan, meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7, 7'-epoxylignan, and (E)-4,4'-dihydroxy-7,7'-dioxolign- 8(8')-ene, together with 10 known compounds, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR spectroscopic analysis. Their antioxidant activities against intracellular reactive oxygen species were evaluated in HL-60 cells. © 2004 Published by Elsevier Ltd.
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    Triterpene saponins from Nigella sativa L
    (2005) Taşkin M.K.; Alankuş Çalişkan Ö.; Anil H.; Abou-Gazar H.; Khan I.A.; Bedir E.
    Three known triterpene glycosides were isolated from the MeOH extract of dried and powdered seeds of Nigella sativa. The structures of the compounds were established as 3-O-[ß-D-xylopyranosyl-(1›3)-?-L- rhamnopyranosyl-(1›2)-?-L-arabinopyranosyl]-28-O-[?-L- rhamnopyranosyl-(1›4)-ß-D-glucopyranosyl(1›6)-ß-D- glucopyranosyl]-hederagenin (1), 3-O-[?-L-rhamnopyranosyl-(1›2)- ?-L-arabinopyranosyl]28-O-[?-L-rhamnopyranosyl-(1›4) -ß-D-glucopyranosyl-(1›6)-ß-D-glucopyranosyl]-hederagenin (2), and 3-O-[ß-D-xylopyranosyl-(1›3)-?-L-rhamnopyranosyl-(1›2)- ?-L-arabinopyranosyl] -hederagenin (3) by means of chemical and spectral methods. Compound 2 was isolated for the first time from the genus Nigella. © TÜBİTAK.