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    Antihyperglycemic and antihyperlipidemic effects of ferula assa-foetida and ferula tenuissima extracts in diabetic rats
    (Asian Network for Scientific Information, 2015) Yusufoglu H.S.; Soliman G.A.; Abdel-Rahman R.F.; Abdel-Kader M.S.; Ganaie M.A.; Bedir E.; Erel Ş.B.; Öztürk B.
    The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg kg-1) and F. tenuissima (400 mg kgG1) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kg-1) and F. tenuissima (400 mg kg-1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity. © 2015 Asian Network for Scientific Information.
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    Antioxidant and antihyperglycemic effects of ferula durdeana and ferula huber-morathii in experimental diabetic rats
    (Asian Network for Scientific Information, 2015) Yusufoglu H.S.; Soliman G.A.; Abdel-Rahman R.F.; Abdel-Kader M.S.; Genaie M.A.; Bedir E.; Erel Ş.B.; Öztürk B.
    In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to estimate the potential in vitro antioxidant effect of the methanol extracts of Ferula durdeana Korovin (F. durdeana) and Ferula huber-morathii Peşmen (F. huber-morathii). The antidiabetic activity of both extracts was evaluated in streptozotocin (STZ)-induced diabetic rats. Glibenclamide was taken as the standard drug. Both extracts showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant assay. Oral administration of F. durdeana (400 mg kg-1) and F. huber-morathii (200 and 400 mg kg-1) extracts to diabetic rats produced a marked reduction in Fasting Blood Glucose (FBG) and elevation in insulin levels after 14 and 28 days of treatment. A meaningful reduction in the concentrations of glycosylated hemoglobin (HbA1c), triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein (LDL) in plasma and elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals medicated with F. durdeana (200 and 400 mg kg-1) and F. huber-morathii (400 mg kgG1) extracts. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. durdeana and F. huber-morathii-medicated diabetic rats. Besides, biochemical results were supported by histopathological findings. These findings showed the significant antioxidant and hypoglycemic activities of F. durdeana and F. huber-morathii extracts in diabetic rats. © 2015 Asian Network for Scientific Information.
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    Hepatoprotective activities of Astragalus persicus and Astragalus tournefortii ethanolic extracts against paracetamol induced liver damage in rats and their in vitro antioxidant effects
    (Society of Pharmaceutical Sciences of Ankara (FABAD), 2013) Soliman G.A.E.-H.; Abdel-Rahman R.F.; Al-Saikhan F.I.; Alankuş-Çalişkan O.; Alqasoumi S.I.; Yusufoglu H.S.
    The aim of this study was to investigate the potential hepatoprotective effect of the ethanol extracts of Astragalus persicus (DC.) Fisch. & C.A.Mey (A. persicus) and Astragalus tournefortii Boiss (A. tournefortii) in a rat model of paracetamol (PCM) induced liver damage. PCM administration caused severe hepatic damage in rats as evidenced by elevated serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), ?-glutamyl transferase (?-GT) and serum level of total bilirubin (BRN), while decreased serum level of total protein (TP) and albumin (ALB). In liver homogenates, PCM elevated malondialdehyde (MDA) but decreased glutathione (GSH) level as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities. Administration of A. persicus and A. tournefortii extracts (200 and 400 mg/kg) for 7 days before PCM inhibited the acute elevation of the serum activities of AST, ALT, ALP and ?-GT enzymes and serum level of BRN. PCMinduced lipid peroxidation was likewise attenuated by both extracts. Similarly, both extracts increased the activities of the antioxidant enzymes (GPx, SOD, CAT) and reduced GSH concentration in the liver homogenates. The results of the in vitro antioxidant effect revealed considerable antioxidant activity for both extracts. The median effective concentration (EC50) values of A. persicus and A. tournefortii extracts and ascorbic acid for DPPH radical scavenging activities were 6455, 6199 and 75.62 ìg/ml, respectively. It was concluded that A. persicus and A. tournefortii possess hepatoprotective activities that could be partly attributed to their antioxidant effects.