Yazar "Abdel-Rahman, Rehab F." seçeneğine göre listele

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    Antihyperglycemic and Antihyperlipidemic Effects of Ferula duranii in Experimental Type 2 Diabetic Rats
    (Asian Network Scientific Information-Ansinet, 2015) Yusufoglu, Hasan S.; Soliman, Gamal A.; Abdel-Rahman, Rehab F.; Abdel-Kader, Maged Saad; Ganaie, Majid A.; Bedir, Erdal; Baykan, Sura; Ozturk, Bintug
    In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to evaluate in vitro antioxidant potential of the methanol extract of Ferula duranii (F. duranii). The antihyperglycemic and antihyperlipidemic activities of F. duranii extract were evaluated in streptozotocin (STZ)-induced diabetic rats. F. duranii showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant power assay. A meaningful reduction in the concentrations of Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb Alc), triglycerides (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL-C) in plasma and an elevation in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) in hepatic and pancreas homogenates were observed in diabetic animals medicated with F. duranii extract in comparison with diabetic control rats. The level of insulin raised significantly in plasma of diabetic groups received F. duranii in respect to diabetic control one. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL-C) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. duranii-medicated diabetic rats in comparison with diabetic controls. The present data suggest that F. duranii has both antidiabetic and antihyperlipidemic effects.
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    Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats
    (Asian Network Scientific Information-Ansinet, 2015) Yusufoglu, Hasan S.; Soliman, Gamal A.; Abdel-Rahman, Rehab F.; Abdel-Kader, Maged Saad; Genaie, Majid A.; Bedir, Erdal; Erel, Sura Baykan; Ozturk, Bintug
    In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to estimate the potential in vitro antioxidant effect of the methanol extracts of Ferula drudeana Korovin (F. drudeana) and Ferula huber-morathii Pesmen (F. huber-morathii). The antidiabetic activity of both extracts was evaluated in streptozotocin (STZ)-induced diabetic rats. Glibenclamide was taken as the standard drug. Both extracts showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant assay. Oral administration of F. drudeana (400 mg kg(-1)) and F. huber-morathii (200 and 400 mg kg(-1)) extracts to diabetic rats produced a marked reduction in Fasting Blood Glucose (FBG) and elevation in insulin levels after 14 and 28 days of treatment. A meaningful reduction in the concentrations of glycosylated hemoglobin (HbA1c), triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein (LDL) in plasma and elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals medicated with F. drudeana (200 and 400 mg kg(-1)) and F. huber-morathii (400 mg kg(-1)) extracts. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. drudeana and F. huber-morathii-medicated diabetic rats. Besides, biochemical results were supported by histopathological findings. These findings showed the significant antioxidant and hypoglycemic activities of F. drudeana and F. huber-morathii extracts in diabetic rats.
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    The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats
    (Sciencedomain Int, 2020) Foudah, Ahmed, I; Alqarni, Mohammed H.; Soliman, Gamal A.; Abdel-Rahman, Rehab F.; Alankus-Caliskan, Ozgen; Ganaie, Majid A.; Yusufoglu, Hasan
    The current study aimed to estimate in vitro antioxidant effect of Astragalus davisii (A. davisii) extract. Further, the possible protective effect of A. davisii against paracetamol (PCM)-induced liver injury was assessed in rats. A. davisii was tested for its antioxidant activity using DPPH radical scavenging assay. the hepatoprotective potential of the extract was assessed in rats following oral administration for 7 days. Liver injury was induced in rats following oral administration of PCM overdose. Hepatic biomarkers; alanine-aminotransferase, aspartate-aminotransferase, alkaline-phosphatase, gamma-glutamyl transferase and bilirubin were increased, while total protein and albumin were reduced in PCM control animals. Additionally, the activities of superoxide dismutase (SOD), catalase and glutathione-peroxidase (GPx) and the levels of glutathione were significantly declined, while levels of hepatic malondialdehyde (MDA) were significantly elevated in PCM alone treated rats. Oral administration of A. davisii (400 mg/kg) prior to PCM inhibited the elevation in the levels of liver damage markers in serum and protected against oxidative stress. Histopathological remarks confirmed the hepatoprotective potential of the extract. the results suggest that A. davisii extract at 400 mg/kg protects liver against injury induced by PCM overdose.