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Öğe Analysis of physical activity intensity, alexithymia, and the COMT val 158 met gene polymorphism(Kamla-Raj Enterprises, 2014) Zekioglu A.; Çam F.S.; Mutlutürk N.; Berdeli A.; Çolakoglu M.The researchers investigated the relationship between intense training, the catechol-Omethyltransferase (COMT) Val108/158Met gene polymorphism, and alexithymia. Eighteen female and 77 male athletes were included. The Toronto Alexithymia Scale (TAS) questionnaire and polymerase chain reaction method were used to evaluate alexithymia and the COMT gene Val108/158Met polymorphism, respectively. Fifteen (15.8%) subjects were evaluated as alexithymic and 80 (84.2%) were non-alexithymic according to the TAS. The COMT Vall08/158 Met gene polymorphism frequencies were as follows: 17.9% Met/Met, 50.5% Val/Met, and 31.6% Val/Val. No difference were observed among training intensity, the COMT Vall08/158 Met gene polymorphism, and alexithymia(p > 0.05). However, 60% of the alexithymic subjects trained intensively and only 6.7% trained lightly. Intensive and light training rates for non-alexithymic athletes were 46.3% and 20%, respectively. The Val/ Val and Met/Met genotyping rates for athletes engaged in intensive training were 32.6% and 29.3%. In conclusion, no significant relationship was observed among TAS scores, the COMT gene polymorphism, and training intensity. © Kamla-Raj 2014.Öğe Association of angiotensin-converting enzyme I/D and eNOS G894T gene polymorphisms with erectile dysfunction [Converting enzim I/D ve eNOS G894T gen polimorfi{dotless}zmlerinin erektil disfonksiyon ile ilişkisi](Turkiye Klinikleri, 2011) Çam F.S.; Gümüş B.H.; Var A.; Berdeli A.Objective: Recent studies suggest that angiotensin II and nitric oxide (NO) may modulate penile smooth muscle tone and contractility. Because genotypes of the angiotensin converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with disorders in the vascular system, in this study, we investigated an association between the ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction (ED). Material and Methods: A total of 44 patients and 45 control subjects were included in the study. Diagnosis of erectile dysfunction (< 26) was provided by International Index of Erectile Function (IIEF). The ACE I/D ve eNOS G894T gene polymorphisms were genotyped using PCR and RFLP. Results: No significant case-control difference was observed for the ACE I/D and eNOS G894T gene polymorphisms either by genotype or allele frequencies [(ACE I/D-X2= 0.930 p= 0.628) and eNOS 894 G/T-X2= 2.114 p = 0.348)]. In addition, there was no significant difference between ACE I/D (X2= 3.174 p= 0.787) and eNOS G894T (X2= 4.320 p= 0.633) and IIEF scores among the patient group. Conclusion: In this study, no association was found between ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction in the Turkish population studied. © 2011 by Türkiye Klinikleri.Öğe Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients(2006) Şekuri C.; Çam F.S.; Tengiz I.; Ercan E.; Bayturan Ö.; Berdeli A.Objective: Platelet-activating factor (PAF) is a phospholipid with multiple actions that is involved in inflammatory diseases as well as in atherogenesis. It is inactivated by a plasma enzyme, PAF-acetylhydrolase (PAF-AH). Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD). Methods: One hundred and fifteen unrelated Turkish patients with a diagnosis of premature CAD and 128 unrelated healthy subjects were enrolled in this study. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The prevalence of the G994T mutation in the patients was 2.60 % (heterozygote), and 0 % in the controls. There was no significant difference in allele frequency and genotype distribution among the study groups. Conclusion: The G9943T mutation in the plasma PAF acetylhydrola se gene is not associated with premature CAD in Turkish subjects.Öğe The attitudes of medical students toward the elderly [Tip fakültesi öğrencilerinin yaşlilara karşi tutumlari](Geriatrics Society, 2015) Elbi H.; Altan S.; Rahman S.; Cengiz Özyurt B.; Şahin S.; Çam F.S.Introduction: Health workers must be prepared for the changes and developments due to the ever-increasing proportion of elderly individuals within the general population. This study aimed to identify the general attitudes of students of the Faculty of Medicine of Celal Bayar University (CBU) toward senility and evaluate differences in the attitudes of students at different stages of medical education. Materials and Method: This study was conducted between October and December 2014 and included a total of 406 students attending the Faculty of Medicine of the CBU. A questionnaire form composed of three sections was used to collect data. Results: The age range of study participants was 18-27 years (average age, 21.04 years) 60.8% were females, and 91.4% had a nuclear family structure. When assessing overall UCLA scores according to the stage of medical education, the average scores of first-year students were found to be higher than other year groups. The results of the UCLA questionnaire demonstrated significantly higher overall scores concerning attitudes toward older persons in female students compared with male students. No significant differences in KOGAN questionnaire scores concerning attitudes toward older people were observed between male and female students. Conclusion: The findings of the present study indicate that attitudes toward the elderly change negatively as students progress through medical education. In addition, female students had more positive attitudes toward elderly patients than male students. Considering the expectations from the healthcare providers of the elderly population, who are more fragile compared to normal individuals, it should be envisaged that the responsibilities of physicians have increased. © 2015, Geriatrics Society. All rights reserved.Öğe G protein ß3 subunit gene polymorphism in Turkish hypertensives(2008) Alioglu E.; Ercan E.; Tengiz I.; Yildiz A.; Saygi U.ö.T.S.; Çam F.S.; Berdeli A.Objective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein ß3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein ß3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein ß3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein ß3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (?2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein ß3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein ß3 subunit may be a susceptible gene to essential hypertension.Öğe Personality traits and DRD4, DAT1, 5-HT2A gene polymorphisms in risky and non risky sports participation [Riskli ve risksiz sporlara kati{dotless}li{dotless}mda kişilik özellikleri ile DRD4, DAT1, 5-HT2A gen polimorfizmleri](Turkiye Klinikleri, 2010) Çam F.S.; Çolakoglu M.; Tok S.; Tok I.; Kutlu N.; Berdeli A.Objective: Relationships amongst Big Five personality traits and DRD4, DAT1 and 5-HT2A gene polymorphisms were investigated in 193 college students participating in risky and non-risky sports. Material and Methods: Personality traits were assessed by Five Factor Personality Inventory (FFPI) and gene polymorphisms were analyzed by polymerase chain reaction. Results: In order to examine whether signifant Big Five personality trait differences existed between DAT1 gene polimorphisms, independent sample t-test was used. Results showed that only Agreeableness dimension revealed significant difference indicating that individuals with non-10/10 genotype had higher agreeableness scores when compared to individuals with 10/10 genotype. ANOVA results showed that Big Five personality dimensions scores differed significantly amongst 5-HT2A genotypes. Individuals with CC genotype had lower emotional stability scores when compared to individuals with TC genotype, and CC genotype individuals had greater openness to experience scores when compared to TT genotype individuals. Openness to experience scores were also significantly different among DRD4 genotypes. Individuals with ll genotype had greater openness to experience scores when compared to individuals with ss genotype. No 5-HT2A and risky sport participation (RSP) interaction effect was found on emotional change score. Conclusion: DAT1 was not associated with RSP. It was concluded that DRD4 and 5-HT2A were not directly associated with RSP but may be used as indirect predictors of it. © 2010 by Türkiye Klinikleri.
