Ceyhan M.Gürler N.G.Ozsurekci Y.Keser M.Aycan A.E.Gurbuz V.Salman N.Camcioglu Y.Dinleyici E.C.Ozkan S.Sensoy G.Belet N.Alhan E.Hacimustafaoglu M.Celebi S.Uzun H.Oner A.F.Kurugol Z.Ali M.Aygun D.Oncel E.K.Celik M.Yasa O.Akin F.Coşkun Y.2019-10-272019-10-2720142164-5515https://doi.org/10.4161/hv.29678https://hdl.handle.net/11454/26103Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to ? 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis ), Streptococcus pneumoniae ( S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey. © 2014 Taylor & Francis Group, LLCen10.4161/hv.29678info:eu-repo/semantics/openAccessEpidemiologyEtiologic agentsHibMeningitisN. meningitidisS. pneumoniaeSurveillanceTurkeyArticle1092706271225483487Q1