Pögün S.Demirgören S.Kutay F.Z.Hariri N.I.Karaali H.2019-10-272019-10-2719890278-5846https://doi.org/10.1016/0278-5846(89)90014-6https://hdl.handle.net/11454/243911. The binding of 3H-Naloxone to opiate receptors was characterized in the frontal cortex of human post-mortem brain samples and age related changes in opiate receptors were investigated. 2. Our study revealed the presence of two binding sites with different affinities for naloxone. 3. With increasing age, the opiate receptors tend to show greater affinity for the agonistic conformation; this may imply a decline in endogenous opioid peptides with age. © 1989.en10.1016/0278-5846(89)90014-6info:eu-repo/semantics/closedAccessAgingnaloxoneopiate receptorpost-mortem human brainArticle1301.Feb1671712546178N/A