Özgüney I.S.Karasulu H.Y.Kantarci G.Sözer S.Güneri T.Ertan G.2019-10-272019-10-2720061530-9932https://doi.org/10.1208/pt070488https://hdl.handle.net/11454/21635The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of w/o microemulsion (M) and gel (G) bases for diclofenac sodium (DS). The effect of dimethyl sulfoxide (DMSO) as a penetration enhancer was also examined when it was added to the M formulation. To study the in vitro potential of these formulations, permeation studies were performed with Franz diffusion cells using excised dorsal rat skin. To investigate their in vivo performance, a carrageenan-induced rat paw edema model was used. The commercial formulation of DS (C) was used as a reference formulation. THe results of the in vitro permeation studies and the paw edema tests were analyzed by repeated-measures analysis of variance. The in vitro permeation studies found that M was superior to G and C and that adding DMSO to M increased the permeation rate. The permeability coefficients (Kp) of DS from M and M+DMSO were higher (Kp = 4.9 × 10-3 ± 3.6 × 10-4 cm/h and 5.3 × 10-3 ± 1.2 × 10-3 cm/h, respectively) than the Kp of DS from C (Kp = 2.7 × 10-3 ± 7.3 × 10-4 cm/h) and G (Kp = 4.5 × 10-3 + 4.5 × 10-5 cm/h). In the paw edema test, M showed the best permeation and effectiveness, and M+DMSO had nearly the same effect as M. The in vitro and in vivo studies showed that M could be a new, alternative dosage form for effective therapy. Copyright ©2006. All Rights Reserved.en10.1208/pt070488info:eu-repo/semantics/closedAccessCarrageenan-induced rat paw edema testDiclofenac sodiumIn vitro permeationMicroemulsionArticle7417233540Q2