Sarisozen, CanArica, BetuelOrman, Mehmet N.Hincal, A. AtillaCalis, Sema2019-10-272019-10-2720101071-7544https://doi.org/10.3109/10717541003667780https://hdl.handle.net/11454/43949Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2<SU3</SU) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 +/- 6.7%) and encapsulation efficiency (45.7 +/- 0.3%), and released the drug at a constant rate in 11 days.</.en10.3109/10717541003667780info:eu-repo/semantics/closedAccessMicrospheresprednisolone acetatechitosanfactorial designspray-dryingArticle173178186WOS:00027565580001120196705Q3