Sakin, Yusuf SerdarBor, Serhat2026-09-262026-09-2620251841-87241842-1121https://doi.org/10.15403/jgld-6237https://hdl.handle.net/11454/134481Proton pump inhibitors (PPIs) one of the most prescribed drugs worldwide, inhibit acid secretion in the stomach by irreversible hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) blocking. Currently conventional PPIs in markets are mainly in racemic forms (containing both R- and S- forms). It has been suggested that the beneficial effects of racemic PPIs mostly depend on one of the enantiomers, and a drug containing pure enantiomers might be superior to racemic PPIs. Enantiomers are mirror image stereoisomers of a molecule. In this article, we aim to analyze the comparative studies of the enantiomers of PPIs with non-racemic counter-parts and to assess whether enantiomers, as suggested by certain studies and primarily promoted by some pharmaceutical companies, demonstrate superior efficacy.en10.15403/jgld-6237info:eu-repo/semantics/openAccessProton Pump InhibitorPpiEnantiomerReview Article344515520WOS:0016559790000182-s2.0-10502611584441453105Q3Q3