Karaaslan, Muhammet AliParlak, Hatice2019-10-272019-10-2720161018-46191610-23041018-46191610-2304https://hdl.handle.net/11454/53211Pharmaceutically active compounds have attracted great attention last decades because of their potential environmental affects. Beside the expected impacts, depends on the concentrations of pharmaceuticals, unexpected side effects also can be occurred. In our study the effects of Atenolol, propranolol, metoprolol and nadolol are being investigated by embryos of sea urchin Paracentrotus lividus which is one of important member of aquatic ecosystems. According to our results the EC50 values of embryotoxicity are 0,232 mg/l for Propranolol; 9,32 mg/l for Metoprolol, 33,802 mg/l for Atenolol and 53,08mg/l for Nadolol. Also we detect some chromosomal abnormality like mitotic bridge and scattered formations. According to the results, we can have concluded that beta blockers have effects on embryonic development of sea urchin and these effects can be seen on embryonic stages, larval development and cytotoxic level.eninfo:eu-repo/semantics/closedAccessBeta blockerssea urchinembryotoxicitygenotoxicityArticle2512A61006105WOS:000392555800057Q4