Ergenoglu M.Yildirim N.Yildirim A.G.S.Yeniel O.Erbas O.Yavasoglu A.Taskiran D.Karadadas N.2019-10-262019-10-2620151933-7191https://doi.org/10.1177/1933719115570900https://hdl.handle.net/11454/16927Objective: To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS). Study Design: After PCOS model was formed by subcutaneous dihydrotestosterone pellets, rats were randomly divided into 2 groups. The first group (n = 7) was treated with 1 mL/kg/d isotonic saline and the second group (n = 7) was treated with 10 mg/kg/d resveratrol. Seven rats were taken as controls without any medication. Results: Our results showed (1) significant reduction in the number of antral follicle counts (P < .01); (2) significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (P < .01 and P < .05, respectively); (3) significantly lower superoxide dismutase activity (P < .05); and (4) significantly increased glutathione peroxidase content (P < .01) following resveratrol treatment. Conclusion: Resveratrol appears to be effective in the treatment of PCOS due to its antioxidant properties. Future clinical studies with different dosages might provide useful implementations to our practice. © The Author(s) 2015.en10.1177/1933719115570900info:eu-repo/semantics/closedAccessanti-Mullerian hormoneoxidative stresspolycystic ovary syndromerat modelresveratrolArticle22894294725667201Q2