Hariri N.Falakali B.Algan O.2019-10-272019-10-271994https://hdl.handle.net/11454/24115Contradictory results have been reported in different brain regions with regard to age-related morphological ranges. In the present study, the number of synapses (Nv), the mean synaptic length (S), and the total synaptic length of synapses/micrograph (Sv) were measured using quantitative morphometric techniques in E-PTA stained sections of the olfactory bulb from adult (12 months), old (30 months), and Hydregine-treated old (30 months) rats. In old animals, Nv and Sv were reduced; however, S was significantly increased when compared with adults. Hydergine (Codergocrine mesylate) treatment of old animals (3 mg/kg/b.w./day for 4 weeks) influenced these parameters differently: in old Hydergine-treated animals, Sv and Nv were higher and S was significantly smaller, when compared with the untreated old group. All the parameters studied were not statistically different when Hydergine-treated old rats were compared with adult animals. The present findings have been interpreted as a modulating effect of Hydergine on the morphological plasticity of the olfactory bulb synapses.eninfo:eu-repo/semantics/closedAccessagingE-PTA staininghydergine (Codergocrine mesylate)olfactory bulbsynaptic plasticityArticle2128185N/A