Aykut-Yetkiner A.Kara N.Ateş M.Ersin N.Ertuğrul F.2019-10-262019-10-2620141053-4628https://doi.org/10.17796/jcpd.38.4.b4q401v6m4818215https://hdl.handle.net/11454/17431OBJECTIVE: The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization.STUDY DESIGN: The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis.RESULTS: DIAGNOdent measurements were increased by time (p = 0.002) in control group and no statistically significant diference (p = 0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period.CONCLUSIONS: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.en10.17796/jcpd.38.4.b4q401v6m4818215info:eu-repo/semantics/closedAccessArticle38430230625571679Q3