Hasanov, SamirBiler, Elif DemirkilincAcarer, AhmetAkkin, CezmiColakoglu, ZaferUretmen, Onder2019-10-272019-10-2720190165-57011573-2630https://doi.org/10.1007/s10792-018-0934-yhttps://hdl.handle.net/11454/28946Meeting of the Turkish-Ophthalmology-Society -- 2016 -- Antalya, TURKEYPurposeTo evaluate and follow-up of functional and morphological changes of the optic nerve and ocular structures prospectively in patients with early-stage Parkinson's disease.Materials and methodsNineteen patients with a diagnosis of early-stage Parkinson's disease and 19 age-matched healthy controls were included in the study. All participants were examined minimum three times at the intervals of at least 6month following initial examination. Pattern visually evoked potentials (VEP), contrast sensitivity assessments at photopic conditions, color vision tests with Ishihara cards and full-field visual field tests were performed in addition to measurement of retinal nerve fiber layer (RNFL) thickness of four quadrants (top, bottom, nasal, temporal), central and mean macular thickness and macular volumes.ResultsBest corrected visual acuity was observed significantly lower in study group within all three examinations. Contrast sensitivity values of the patient group were significantly lower in all spatial frequencies. P100 wave latency of VEP was significantly longer, and amplitude was lower in patient group; however, significant deterioration was not observed during the follow-up. Although average peripapillary RNFL thickness was not significant between groups, RNFL thickness in the upper quadrant was thinner in the patient group. While there was no difference in terms of mean macular thickness and total macular volume values between the groups initially, a significant decrease occurred in the patient group during the follow-up. During the initial and follow-up process, a significant deterioration in visual field was observed in the patient group.ConclusionStructural and functional disorders shown as electro-physiologically and morphologically exist in different parts of visual pathways in early-stage Parkinson's disease.en10.1007/s10792-018-0934-yinfo:eu-repo/semantics/closedAccessParkinson's diseaseContrast sensitivityColor visionVisual field analysisVEPOCTRNFL thicknessMacular thicknessMacular volumeArticle39612551262WOS:00046988870000829744762Q4