Barutçuoglu B.Bozdemir A.E.Ertan Y.Kabaroglu C.Tamsel S.Hekimgil M.Çal Ç.Özmen D.Bayindir O.2019-10-262019-10-2620091019-31031019-3103https://hdl.handle.net/11454/20411The aim of the study was to report the diagnostic performance of total prostate-specific antigen (tPSA) and free prostate-specific antigen ratio (%fPSA). The diagnostic performances of tPSA and %fPSA were evaluated in 364 men by ROC curves, sensitivity, specificity and diagnostic odds ratio calculations. One hundred and sixty-two patients were diagnosed as prostate cancer (PCa) and 202 as normal. The median tPSA levels and %fPSA ratios differed significantly, 11.16 ng/mL and 11 versus 6.51 ng/mL and 20 in PCa and normal groups, respectively. At tPSA levels between 4-10 ng/mL; area under curve (AUC)%fPSA was greater than AUCtPSA. 1 as a cut off value of %fPSA was the optimum choice revealing a sensitivity of 0.703, a specificity of 0.656 and diagnostic odds ratio of 4.254(95% CI 2.157- 8.39 ). %fPSA ratio is an expedient screening marker in PCa. In our laboratory, at tPSA levels between 4-10 ng/mL, %fPSA ratio of 1 offers a preferable diagnostic performance.eninfo:eu-repo/semantics/closedAccessFree prostate specific antigen ratioProstate cancerTotal prostate specific antigenArticle3911825N/A