Shademan, BehrouzNourazarian, AlirezaHajazimian, SabaIsazadeh, AlirezaBiray Avci, CigirOskouee, Mahin Ahangar2023-01-122023-01-1220222296-889Xhttps://doi.org/10.3389/fmolb.2021.772788https://hdl.handle.net/11454/78462Outbreak and rapid spread of coronavirus disease (COVID-19) caused by coronavirus acute respiratory syndrome (SARS-CoV-2) caused severe acute respiratory syndrome (SARS-CoV-2) that started in Wuhan, and has become a global problem because of the high rate of human-to-human transmission and severe respiratory infections. Because of high prevalence of SARS-CoV-2, which threatens many people worldwide, rapid diagnosis and simple treatment are needed. Genome editing is a nucleic acid-based approach to altering the genome by artificially changes in genetic information and induce irreversible changes in the function of target gene. Clustered, regularly interspaced short palindromic repeats (CRISPR/Cas) could be a practical and straightforward approach to this disease. CRISPR/Cas system contains Cas protein, which is controlled by a small RNA molecule to create a double-stranded DNA gap. Evidence suggested that CRISPR/Cas was also usable for diagnosis and treatment of SARS-CoV-2 infection. In this review study, we discoursed on application of CRISPR technology in detection and treatment of SARS-CoV-2 infection. Another aspect of this study was to introduce potential future problems in use of CRISPR/Cas technology.en10.3389/fmolb.2021.772788info:eu-repo/semantics/openAccesscoronavirusesSARS-CoV-2CRISPRCas9gene editingACE-2 receptorsSpike ProteinSars-CovCoronavirusReceptorHostTargetIdentificationArchitectureReplicationDiagnosticsReview8WOS:0007480553000012-s2.0-8512344442735087864Q1Q2