Uyar M.Uyar M.Mert S.Ozyar B.Bilge S.Ugur G.Gokce B.2019-10-272019-10-2719961016-51501016-5150https://hdl.handle.net/11454/23884The effects of 0.15 mg clonidine and 2 mg lorazepam premedication on sedation, anxiety, hemodynamic response to induction and laryngoscopy, IV anesthetic close and recovery were compared with placebo in 45 ASA I-II patients undergoing urological surgery under general anesthesia. Sedation was assessed by 3-point scale, anxiety by Lineer Anxiety Score (0-100 mm) and State-Trait Anxiety Inventory, induction duality by 4-point scale and amnesia by whether the patient remembered 5 different events 3 hours after the operation. Clonidine and lorazepam produced more sedation and less anxiety than placebo (p<0.05). Hemodynamic response to intubation was not prevented in all groups. Quality of induction was better and propofol dose was lower in clonidine group (p<0.05). Amnesia was more marked in lorazepam group (p<0.05). Time to eye opening, orientation and first analgesic request was not different among the three groups. Oral clonidine premedication was found to be a good alternative to benzodiazepines for routine use with regard to its effects on sedation, anxiolysis, induction quality and induction dose of propofol.trinfo:eu-repo/semantics/closedAccessClonidineLorazepamPremedicationArticle244166171N/A