Özşener S.Akercan F.Çirpan T.Coşan Terek M.Itil I.M.Yücebilgin S.2019-10-272019-10-2720051016-51261016-5126https://hdl.handle.net/11454/22042OBJECTIVE: The comparison of the effects of hormone replacement therapy with pulse estrogen-medroxyprogesterone acetate and conjugated estrogene-medroxyprogesterone acetate on vasomotor complaints and uterine bleeding patterns in physiologic postmenopausal patients. STUDY DESIGN: Total 80 cases who were admitted to Ege University Medical Faculty Gynecology Department's Menopause Clinic between January 2002-January 2004 and using these regimens were included for this retrospective study. The hormone replacement therapy preperations which were the subject of this study were: the combination of estradiol hemihydrate (aerodiol, 150 meg, Servier) and medroxyprogesterone acetate (Farlutal, 5 mg, Deva) as pulsed estrogen-MPA and estrogen 0,625 mg and medroxyprogesterone acetate 5 mg (Premelle Cycle, Wyeth) as conjugated estrogen-MPA combination. There were 30 cases in pulsed estrogen-MPA group and 50 patients in conjugated estrogen-MPA group. RESULTS: The average age of the patients was 50.912.5 years. There were no significant difference between the age, menopausal age, body-mass index (BMI) and postmenopausal period of the groups (p>0.05). There were no significant difference in hot flush frequencies (average 8.60±3.23) (p>0.05). Kupperman index values on initial, third and sixth months were 27.3±4.8; 10.2±2.9; 9.5±2.7 in pulsed estrogene-MPA group and 7.9±5.9; 10.5±2.3 ve 10.2±2.1 in conjugated estrogen-MPA group and no significant difference were found between the groups (p>0.05). The withdrawal bleeding was seen more frequently in oral conjugated estrogen-MPA group. But the difference was not significant (p=0.061). In the same way, the irregular bleeding (every bleeding pattern except withdrawal bleeding) episodes were seen in conjugated estrogen-MPA group more than the other group but, the difference was not significant (p=0.426). CONCLUSION: The efficacy and tolerability of pulse estrogene-MPA therapy in physiological postmenopausal patients was similar to oral conjugated estrogene-MPA therapy and could be used as an effective therapeutic choice.trinfo:eu-repo/semantics/closedAccessConjugated EstrogenMedroxyprogesterone AcetatePulsed EstrogenArticle1928184N/A