Akdemir A.Sahin C.Erbas O.Yeniel A.O.Sendag F.2019-10-262019-10-2620150932-0067https://doi.org/10.1007/s00404-015-3646-9https://hdl.handle.net/11454/16933Purpose: Ursodeoxycholic acid is frequently used in cholestatic liver diseases. Also, it protects hepatocytes against oxidative stress induced by hydrophobic bile acids. We investigated the anti-oxidative effect of ursodeoxycholic acid on ischemia/reperfusion injury after ovarian de-torsion in rats. Methods: We designed five study groups. Group 1 (n = 6): Sham-operated group; group 2 (n = 6): torsion group; group 3 (n = 6): torsion and ursodeoxycholic acid, group 4 (n = 7): torsion/de-torsion group; and group 5 (n = 7): torsion/de-torsion and ursodeoxycholic acid. After that, ovarian samples were obtained and examined histologically and tissue levels of malondialdehyde were measured. Results: Follicular degeneration, edema and inflammatory cells were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Also, groups 4 and 5 were compared in terms of vascular congestion and hemorrhage and these were found to be significantly decreased in group 5. In addition, levels of malondialdehyde were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Conclusions: We concluded that ursodeoxycholic acid might be useful to protect the ovary against ischemia and reperfusion injury. © 2015, Springer-Verlag Berlin Heidelberg.en10.1007/s00404-015-3646-9info:eu-repo/semantics/closedAccessIschemia/reperfusion injuryOvarian torsionOxidative stressUrsodeoxycholic acidArticle292244545025663134Q2