Sin, A. Z.Ersoy, R.Gulbahar, O.Ardeniz, O.Gokmen, N. M.Kokuludag, A.2019-10-272019-10-2720081018-9068https://hdl.handle.net/11454/40919Background and objective: Pollens from the Cupressaceae family are considered important allergens in the Mediterranean area, though reports of the prevalence of allergic symptoms have ranged from 1.04% to 35.4%. Our aim was to detect the prevalence of cypress pollen sensitization and determine its clinical importance in patients with seasonal respiratory allergy. Methods: We used skin prick tests (SPT) and serum specific IgE assays to reveal sensitization to cypress pollen. In patients who showed positive results to cypress pollen, a nasal provocation test (NPT) with pollen extract was used to assess the target organ response. Results: Sixty-five (14.3%) of 455 patients showed positive SPT responses to Cupressus sempervirens extract. Only I patient was monosensitized while 64 patients were polysensitized. Among those, 2 pollen cosensitizations were found to be significant (86% were cosensitized to grasses and 72% were cosensitized to olive (P <.001). Serum specific IgE to cypress pollen was measured in 50 of the 65 patients; findings were positive for 37. When these 37 patients underwent NPT with C sempervirens allergen extract, only the single monosensitized patient had a positive NPT. Conclusion: A positive SPT to cypress pollen may not reflect the true prevalence of sensitization. We assume that in the absence of a positive NPT, positive SPT results might be related to the presence of cross-reactivity between pollen species.eninfo:eu-repo/semantics/closedAccessallergycypress pollencross-reactivitynasal provocationArticle1814651WOS:00025338860000818361102Q3N/A