Demir, EmreCeylan, NaimBayraktaroglu, SelenCinkooglu, AkinCandemir, AytacCandemir, Yesim B.Gunes, Mustafa Talha2023-01-122023-01-1220220742-28221540-8175https://doi.org/10.1111/echo.15498https://hdl.handle.net/11454/77522ObjectivePeripartum cardiomyopathy (PPCM) diagnosis made by excluding identifiable causes of heart failure (HF) and occurs end of the pregnancy or during the postpartum period of five months. It presents a clinical HF spectrum with left ventricular systolic dysfunction. BackgroundThe purpose of this study is to retrospectively evaluate the clinical characteristics, cardiac magnetic resonance (CMR) imaging features, and end-points consisting of left ventricle recovery, left ventricular assist device implantation, heart transplantation, and all-cause mortality. MethodOutpatient HF records between 2008 to 2021 were screened. Thirty-seven patients were defined as PPCM. Twenty-five patients had CMR evaluation at the time of diagnosis, and six patients were re-evaluated with CMR. ResultsThe mean age was 30.5 +/- 5.6 years, and the mean LVEF was 28.2% +/- 6.7%. In 13(35.7%) patients, LVEF recovered during the follow-up course. The median recovery time was 281(IQR [78-358]) days. LVEF on CMR was 35.3 +/- 10.5, and three patients exhibited late gadolinium enhancement(LGE) patterns. Sub-endocardial and mid-wall uptake pattern types were detected. 18(75%) patients met the Petersen left ventricle non-compaction cardiomyopathy(LVNC) criteria. Patients with NC/C ratio lower than 2.3 had lower LVEDVi and LVESVi (124.9 +/- 35.4, 86.4 +/- 7.5, p = .003; 86.8 +/- 34.6, 52.6 +/- 7.6, p = .006), respectively. The median follow-up time was 2129 (IQR [911-2634]) days. The primary endpoint-free 1-year survival was 88.9% (event rate 11.1%), and 5-year survival was 75.7% (event rate 24.3%). ConclusionIn a retrospective cohort of PPCM patients, 35.7% of patients' LVEF recovered, and the primary end-point of free-5-year survival was 75%. Twenty-five patients were assessed with CMR; three of four met the Petersen CMR-derived LVNC at initial evaluation.en10.1111/echo.15498info:eu-repo/semantics/openAccesscardiac magnetic resonance imagingnon-compaction cardiomyopathyperipartum cardiomyopathyLeft-Ventricular NoncompactionManagementDiagnosisFeaturesWomenStateArticle391216081615WOS:0008919965000012-s2.0-8514314838436447302Q3Q4