Komesli, Y.Yildirim, Y.Karasulu, E.2020-12-012020-12-0120201347-43671347-4367https://doi.org/10.1016/j.dmpk.2020.10.004https://hdl.handle.net/11454/61686In the present study, the biodistribution of self-microemulsifying drug delivery system of hydrophobic olmesartan medoxomil (OM-SMEDDS) was determined by labeling with a fluorescent dye VivoTag®680 XL and Xenolight® DiR. Labeled OM-SMEDDS and control dye solution administered orally to mice; real-time dynamic biodistributions over 7 h were determined by 2D-fluorescent imaging to verify their anatomic location. Fluorescent Emissions by Vivotag 680® XL and Xenolight® DiR labeled OM-SMEDDS emitted 2 to 24 times stronger emission than control dye administered group. To further confirm the results, organs were removed and examined using the same technique at the end of 7 h. VivoTag®680XL and Xenolight® DiR emitted 4 and 1.7 times stronger emission respectively than control dye administered mice in ex-vivo organ imaging studies. This study showed that OM-SMEDDS can be succesfully labeled with fluorescent dye and tracked with optical imaging method for the visualisation of biodistribution of drugs and is also useful for enhanced bioavailability. © 2020 The Japanese Society for the Study of Xenobioticsen10.1016/j.dmpk.2020.10.004info:eu-repo/semantics/closedAccessBiodistributionNear infrared (NIR)OlmesartanOptical imagingPharmacokineticsReal-time fluorescent imagingSMEDDSVivotagXenolightArticle2-s2.0-8509616197833191089Q2