Dodurga Y.Avci C.B.Satiroglu-Tufan L.N.Susluer S.Y.Sigva O.D.Z.Saydam, G..Gunduz C.2019-10-262019-10-2620121948-59561948-5956https://doi.org/10.4172/1948-5956.1000102https://hdl.handle.net/11454/18892The present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation (URG4/URGCP), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL-60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment. © 2012 Dodurga Y, et al.en10.4172/1948-5956.1000102info:eu-repo/semantics/closedAccessLeukemia cellsQuercetinUrg4/urgcpArticle4169N/A