Hekimgil, MineSoydan, SalihaNart, DenizErtan, YeşimVeral, AliÇağırgan, SeçkinÇetingül, Nazan2020-12-012020-12-0120011300-77771308-5263https://app.trdizin.gov.tr//makale/TVRZeU5qQXchttps://hdl.handle.net/11454/64077The t (2;5) (p23; q35) translocation associated with CDSO-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFM-ALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. in this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal anti-bodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features. the mean age of the pediatric and adult patients was 10-years and 38-years, respectively. ALK1 was positive in 14 cases (35%) representing 83% of pediatric and 26% of adult patients, statistically significantly higher in the pediatric group (p= 0.01). Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALKl-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.eninfo:eu-repo/semantics/openAccessHematolojiOther184265274