Kilcar, Ayfer YurtMuftuler, F. Zumrut BiberMedine, E. IlkerTekin, Volkan2019-10-272019-10-2720160236-57311588-27800236-57311588-2780https://doi.org/10.1007/s10967-016-4746-0https://hdl.handle.net/11454/33475Bioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NCs were characterized utilizing dynamic light scattering and scanning electron microscope. Encapsulation effect on radiolabeling with Tc-99m was examined by stability and lipophilicity studies and effect on in vitro behaviour of Tc-99m-BH was evaluated by incorporation studies on DAOY, U87-MG and A549 cells. It is observed that PLGA encapsulation has a positive and reinforcement effect.en10.1007/s10967-016-4746-0info:eu-repo/semantics/closedAccessBioquin-HMPAOPLGA encapsulationRadiolabelingTc-99mBrain cancer cellsIncorporationArticle3101155164WOS:000383579900016Q2Q2