Emingil, G.Gurkan, A.Atilla, G.Berdeli, A.Cmarcik, S.2019-10-272019-10-2720061023-3830https://doi.org/10.1007/s00011-006-6074-2https://hdl.handle.net/11454/40224Objective and design: The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a over 12-month period. Methods: GCF samples were collected, probing depth (PD), clinical attachment level (CAL), gingival index (GI) and plaque index were recorded at baseline, 3, 6, 9 and 12 months. CP patients (n=65) were randomized to LDD or placebo groups. LDD group received LDD (20mg) b.i.d for 3-months plus scaling and root planing (SRP), while placebo group was given placebo capsules b.i.d for 3-months plus SRP. GCF t-PA levels were determined by ELISA. Friedman, Wilcoxon and Mann-Whitney test was used for statistical analysis. Results: Significant improvement was observed in all clinical parameters in both groups over 12-month period (p < 0.01). LDD group had lower PD, CAL and GI scores than placebo group at 6, 9 and 12-months (p < 0.05). GCF t-PA levels reduced in both groups over 12-month period (p < 0.01). LDD group had lower GCF t-PA levels than placebo group at 6 and 9-months (p < 0.05). Conclusions: These results provide additional information about usefulness of LDD therapy as an adjunct to nonsurgical therapy in long-term management of periodontitis.en10.1007/s00011-006-6074-2info:eu-repo/semantics/closedAccesslow-dose doxycyclinescaling and root planninggingival crevicular fluidGCF t-PAadjunctive therapyArticle5512550558WOS:00024326030000517221169Q1Q4