Tekgul H.Dizdarer G.Demir N.Ozturk C.Tutuncuoglu S.2019-10-272019-10-2720050334-018Xhttps://doi.org/10.1515/JPEM.2005.18.6.585https://hdl.handle.net/11454/22178Dual energy X-ray absorptiometry (DEXA) is a non-invasive, rapid, accurate and highly reproducible method for the assessment of antiepileptic drug (AED)-induced osteopenia in epileptic children. In this study, we investigated bone mineral density (BMD) using DEXA in 56 epileptic children receiving long-term AED treatment for at least 2 years. All children received AED monotherapy or polytherapy plus a standard vitamin D3 supplement (400 U/day). BMD measurements were made from lumbar spine (L2-L4) regions. Age- and sex-specific BMD SD scores were calculated for each child. Osteopenia was defined as SD scores less than -1.5. There was no significant difference in mean BMD values between epileptic children receiving monotherapy or polytherapy. The results were also compared to the age- and sex-specific BMD SD scores obtained from healthy Turkish children. Only three patients (5%) receiving AED therapy had a BMD SD score less than -1.5. This rate is relatively lower than the rates of previous studies conducted on ambulatory children on long-term AED treatment without vitamin D3 supplementation. © Freund Publishing House Ltd., London.en10.1515/JPEM.2005.18.6.585info:eu-repo/semantics/closedAccessAntiepileptic drugBone mineral densityEpilepsyOsteopeniaVitamin DArticle18658558816042326Q2