Içhedef C.Şenocak K.Ertay T.Teksöz S.Medine E.I.Bekiş R.Ünak P.2019-10-262019-10-2620120236-57310236-5731https://doi.org/10.1007/s10967-011-1493-0https://hdl.handle.net/11454/18771The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO) 3] + core in vitro and in vivo. In vitro biological behavior of 99mTc(CO) 3-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). 99mTc(CO) 3-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of 99mTc(CO) 3-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the 99mTc(CO) 3-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that 99mTc(CO) 3-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes. © 2012 Akadémiai Kiadó, Budapest, Hungary.en10.1007/s10967-011-1493-0info:eu-repo/semantics/closedAccess99mTechnetiumCell cultureGuanineImagingArticle2912739743Q2