Kutukculer N.Aksu G.Genel F.Ozturk C.2019-10-272019-10-2720021591-8890https://doi.org/10.1007/s102380200020https://hdl.handle.net/11454/27922The absence of B cells and a severe decrease in CD8+28+ cells were observed in two female children with CD4+ T cell lymphocytopenia. Idiopathic (primary) CD4+ lymphocytopenia is a rare entity and its pathogenesis and genetics are not yet known. The literature was reviewed, in particular for severe alterations in B and CD8+28+ cells and for the role of NF-kappa B and p56lck in the immunopathogenesis. Whether the underlying mechanism in idiopathic CD4+ lymphocytopenia is found or not, these patients who present with severe symptoms of a combined immunodeficiency must be treated with intravenous immunoglobin regularly until they have a compatible donor for bone marrow transplantation.en10.1007/s102380200020info:eu-repo/semantics/closedAccessBone marrow transplantationIntravenous immunoglobulinePrimary (idiopathic) CD4+ lymphocytopeniaArticle2314314612447612Q1