Bayar M.S.Küçükgüçlü S.Gokmen N.Dursun Z.Tuna E.B.Erkan N.2019-10-272019-10-2720060177-99900177-9990https://doi.org/10.1159/000092731https://hdl.handle.net/11454/27664Background: The purpose of this study is to evaluate the nephrotoxicity of sevoflurane inhalation anesthesia applied during carbon dioxide pneumoperitoneum (CO 2-PNP) which is conducted for a laparoscopic surgery treatment. Materials and Methods: 14 New Zealand white rabbits were used in this study. Initially, anesthesia was induced using 3.7% concentrated sevoflurane + 50% O 2/N 2O. Then, a tracheotomy was performed, and the rabbits were mechanically ventilated. The first group (n = 7) was subjected to CO 2-PNP for 90 min with a constant intraabdominal pressure of 12 mm Hg, the second (control group) (n = 7) was exempted. The serum inorganic fluoride (IF -) concentration was measured. The rabbits were sacrificed after 72 h, and one kidney each was immediately extracted for histopathological examination. Results: Serum IF - concentrations were not different in both groups. Histopathologically, mild renal damage was found in one rabbit in each group. Conclusion: CO 2-PNP did not have any additional effect on the nephrotoxicity of sevoflurane. © 2006 S. Karger GmbH.en10.1159/000092731info:eu-repo/semantics/closedAccessLaparoscopic surgeryPneumoperitoneumRabbitSevofluraneArticle2227984N/A