Sarikaya, D.Chiba, I.Bilgen, C.Kamatakil, T., ITopcu, Z.2019-10-272019-10-2720070269-4727https://doi.org/10.1111/j.1365-2710.2007.00841.xhttps://hdl.handle.net/11454/41261Objective: To analyse the expression of individual forms of cytochrome P450 (CYP) at the mRNA level in five homogenized oral buccal tissue samples from four individuals with or without oral malignancy. Method: Individual forms of CYPs were studied by reverse transcriptase-polymerase chain reaction (RT-PCR), using specific primers for CYPs 2B6, 2C, 2D6, 2E1, 3A3/4 and 3A5, and oral CYP expressions were compared with CYP expression in liver tissue. Results: Consistent expression of CYPs 2C, 2E1 and 3A5 was observed in oral buccal tissue at mRNA level. Conclusions: These particular CYPs have possible roles in the protection of the body against orally ingested xenobiotics as well as influence the bioavailability of therapeutic compounds.en10.1111/j.1365-2710.2007.00841.xinfo:eu-repo/semantics/closedAccesscytochrome P450drug metabolizing enzymesoral buccal tissueArticle325445448WOS:00024945040000417875109N/AQ3