Sobanski, VincentGiovannelli, JonathanAllanore, YannickRiemekasten, GabrielaAiro, PaoloVettori, SerenaCozzi, FrancoDistler, OliverMatucci-Cerinic, MarcoDenton, ChristopherLaunay, DavidHachulla, EricCerinic, Marco MatucciGuiducci, SerenaWalker, UlrichKyburz, DiegoLapadula, GiovanniIannone, FlorenzoDistler, OliverMaurer, BrittaJordan, SuzanaBecvar, RadimSierakowsky, StanislawBielecka, Otylia KowalCutolo, MaurizioSulli, AlbertoValentini, GabrieleCuomo, GiovannaVettori, SerenaSiegert, EliseRednic, SimonaNicoara, IleanaKahan, AndreAllanore, YannickVlachoyiannopoulos, PanayiotisMontecucco, CarloCaporali, RobertoStork, JiriInanc, MuratCarreira, Patricia E.Novak, SrdanCzirjak, LaszloVarju, CeciliaChizzolini, CarloKucharz, Eugene J.Kotulska, AnnaKopec-Medrek, MagdalenaWiduchowska, MalgorzataCozzi, FrancoRozman, BlazMallia, CarmelColeiro, BernardGabrielli, ArmandoFarge, DominiqueWu, ChenMarjanovic, ZoraFaivre, HeleneHij, DarinDhamadi, RozaAiro, PaoloHesselstrand, RogerWollheim, FrankWuttge, Dirk M.Andreasson, KristoferMartinovic, DuskaBalbir-Gurman, AlexandraBraun-Moscovici, YolandaTrotta, FrancescoLo Monaco, AndreaHunzelmann, NicolasPellerito, RaffaeleBambara, Lisa MariaCaramaschi, PaolaMorovic-Vergles, JadrankaBlack, CarolDenton, ChristopherDamjanov, NemanjaHenes, JoergOrtiz Santamaria, VeraHeitmann, StefanKrasowska, DorotaSeidel, MatthiasHasler, PaulBurkhardt, HaraldHimsel, AndreaBajocchi, GianluigiNuova, Arcispedale Santa MariaSalvador, Maria JoaoPereira Da Silva, Jose AntonioStamenkovic, BojanaStankovic, AleksandraSelmi, Carlo FrancescoDe Santis, MariaMarasini, BiancaTikly, MohammedAnanieva, Lidia P.Denisov, Lev N.Mueller-Ladner, UlfFrerix, MarcTarner, IngoScorza, RaffaellaPuppo, FrancescoEngelhart, MereteStrauss, GitteNielsen, HenrikDamgaard, KirstenSzucs, GabriellaSzamosi, SzilviaZea Mendoza, Antoniode la Puente, CarlosSifuentes Giraldo, Walter AlbertoMidtvedt, OyvindReiseter, SiljeGaren, TorhildHachulla, EricLaunay, DavidValesini, GuidoRiccieri, ValeriaIonescu, Ruxandra MariaOpris, DanielaGroseanu, LauraWigley, Fredrick M.Cornateanu, Roxana SfrentIonitescu, RazvanGherghe, Ana MariaSoare, AlinaGorga, MarilenaBojinca, MihaiMihai, CarinaMilicescu, MihaelaSunderkoetter, CordKuhn, AnnegretSandorfi, NoraSchett, GeorgDistler, Joerg H. W.Beyer, ChristianMeroni, PierluigiIngegnoli, FrancescaMouthon, LucDe Keyser, FilipSmith, VanessaCantatore, Francesco PaoloCorrado, AdaUllman, SusanneIversen, Linevon Muehlen, Carlos AlbertoBohn, Jussara MariluLonzetti, Lilian ScusselPozzi, Maria RosaEyerich, KilianHein, RuedigerKnott, ElisabethWiland, PiotrSzmyrka-Kaczmarek, MagdalenaSokolik, RenataMorgiel, EwaMadej, MartaHoussiau, Frederic A.Jose Alegre-Sancho, JuanKrummel-Lorenz, BrigitteSaar, PetraAringer, MartinGuenther, ClaudiaWesthovens, Renede Langhe, EllenLenaerts, JanAnic, BranimirBaresic, MarkoMayer, MiroslavUprus, MariaOtsa, KatiYavuz, SuleGranel, BrigitteRadominski, Sebastiao CezarMueller, Carolina de SouzaAzevedo, Valderilio FeijoJimenez, SergioBusquets, JoannaAgachi, SvetlanaGroppa, LilianaChiaburu, LealeaRussu, EugenPopa, SergeiZenone, ThierryPileckyte, MargaritaStebbings, SimonHighton, JohnMathieu, AlessandroVacca, AlessandraSampaio-Barros, Percival D.Yoshinari, Natalino H.Marangoni, Roberta G.Martin, PatriciaFuocco, LuizaStamp, LisaChapman, PeterO'Donnell, JohnSolanki, KamalDoube, AlanVeale, DouglasO'Rourke, MarieLoyo, EsthelaLi, MengtaoMohamed, Walid Ahmed Abdel AttyRosato, EdoardoAmoroso, AntonioGigante, AntoniettaOksel, FahrettinYargucu, FigenTanaseanu, Cristina-MihaelaPopescu, MonicaDumitrascu, AlinaTiglea, IsabelaFoti, RosarioChirieac, RodicaAncuta, CodrinaFurst, Daniel E.Villiger, PeterAdler, Sabinevan Laar, JacobKayser, CristianeEduardo, Andrade Luis C.Fathi, NihalHassanien, Manalde la Pena Lefebvre, Paloma GarciaRodriguez Rubio, SilviaValero Exposito, MartaSibilia, JeanChatelus, EmmanuelGottenberg, Jacques EricChifflot, HeleneLitinsky, IraEmery, PaulBuch, MayaDel Galdo, FrancescoVenalis, AlgirdasButrimiene, IrenaVenalis, PauliusRugiene, RitaKarpec, DianaSaketkoo, Lesley AnnLasky, Joseph A.Kerzberg, EduardoMontoya, FabianaCosentino, VanesaLimonta, MassimilianoBrucato, Antonio LucaLupi, ElideRosner, ItzhakRozenbaum, MichaelSlobodin, GlebBoulman, NinaRimar, DoronCouto, MauraSpertini, FrancoisRibi, CamilloBuss, GuillaumeKahl, SarahHsu, Vivien M.Chen, FeiMcCloskey, DeborahMalveaux, HalinaPasquali, Jean LouisMartin, ThierryGorse, AudreyGuffroy, AurelienPoindron, Vincent2019-10-272019-10-2720192326-51912326-5205https://doi.org/10.1002/art.40906https://hdl.handle.net/11454/28699Objective Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. Methods A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. Results Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. Conclusion Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis.en10.1002/art.40906info:eu-repo/semantics/closedAccessPhenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic SclerosisArticle71915531570WOS:00048083780000130969034Q1