Altunişik U.Karaman S.Günüşen I.Firat V.2019-10-262019-10-2620071304-08711304-0871https://hdl.handle.net/11454/21426Aim: The efficacy of esmolol, remifentanil and esmolol+remifentanil on changes in heart rate (HR) and arterial blood pressure (ABP) after laryngoscopy and tracheal intubation were compared. Materials and Methods: Sixty patients (ASAI-II) were included in this study. Before induction HR, systolic and diastolic arterial pressure (SAP and DAP), mean arterial pressure (MAP) and Rate-Pressure Product (RPP: HRxSAP) values were measured three times with 1 minute intervals and the mean value of these measurements was accepted as baseline. Patients were divided into three groups, Group ESM (esmolol group) received 2 mg kg-1 esmolol IV, Group REM (remifentanil group) 1 µg kg-1 remifentanil IV, while Group ESM+REM (esmolol+remifentanil group) received the combination of 1 mg kg-1 esmolol + 0.5 µg kg-1 remifentanil IV. Before induction and intubation and through the 1. to 10. minute after intubation HR, SAP, DAP, MAP was recorded with 1 minute intervals and RPP was calculated according to this data. Results: There was no difference between the groups when demographic data HR, SAP, DAP, MAP and RPP values were compared, but in all groups the HR values were significantly higher at the 1. minute after intubation in comparison with preintubation values. In the remifentanil group measurements showed a significant increase in HR at the 1. minute after intubation when compared to baseline and preinduction measurements. RPP was higher at the 1. minute after intubation in all groups when compared with preintubation values, while the SAP, DAP, and MAP values significantly increased only in esmolol and remifentanil groups (p<0.05). Conclusion: We concluded that, esmolol and esmolol+remifentanil were more effective than remifentanil in preventing hemodynamic response to laryngoscopy and intubation.trinfo:eu-repo/semantics/closedAccessEsmololHemodynamic responseIntubationLaryngoscopyRemifentanilArticle353163168N/A