Tetik, OIslamoglu, FYagdi, TAtay, YCalkavur, TOzbek, CCanpolat, LBuket, SVuksel, M2019-10-272019-10-2720011078-58841532-2165https://doi.org/10.1053/ejvs.2001.1428https://hdl.handle.net/11454/3571449th International Congress of the European-Society-for-Cardiovascular-Surgery -- JUN 24-27, 2000 -- Dresden, GERMANYObjectives: to evaluate the effectiveness of an intraaortic delivered solution on preventing spinal cord injury. Design:forty rabbits were allocated into five equal groups. Materials and Methods: one clamp was placed just distal to the left renal artery, and another was placed just above the iliac bifurcation for 40 min. Group I was not infused (control group). Through a 24G vascular catheter inserted into the isolated aortic segment, 20 nd of LR solution at room temperature (Group 2) 20 ml of LR solution at 3 degreesC (Group 3), and 20 ml of LR solution at 3 degreesC containing 30 mg/kg of methylprednisolone (Group 4) were infused over 3 min. In Group 5, 10mg/kg of vitamins E and C were delivered two days before the experiment, and 20ml of LR solution at 3 degreesC containing 30 mg/kg of methylprednisolone, and 10 mg/kg of vitamins E and C was infused at the operation. Postoperative spinal cord function was assessed using Tarlov's criteria. Results: the neurologic status of Groups 3, 4, and 5 was significantly superior to that of Groups I and 2. No paraplegia was observed in Groups 4 and 5. Spastic paraplegia occurred in all rabbits of Groups I and 2, and in 20% of Group 3. In the electron microscopic evaluation of spinal cord specimens, normal histologic structure was observed in Groups 4 and 5, whereas, some derangements were observed in all others. Conclusions: intraaortic infusion of a hypothermic blended solution containing methylprednisolone, vitamins C and E provided best protection against postischaemic spinal cord dysfunction.en10.1053/ejvs.2001.1428info:eu-repo/semantics/openAccessspinal cord protectionparaplegiaischaemic injuryArticle222175179WOS:00017037970001411472054Q1Q2