Asikoglu M.Yurt F.Cagliyan O.Unak P.Ozkilic H.2019-10-272019-10-2720000969-8043https://doi.org/10.1016/S0969-8043(99)00150-5https://hdl.handle.net/11454/28025The aim of this study was to demonstrate the accumulation of 131I-labeled ornidazole (131I-ORN) in experimental abscesses. 131I-ORN was prepared by electrophilic radioiodination of ORN, using radioiodide in the presence of Iodogen®. An in vivo inflammation model was prepared by intramuscular injection of turpentine into the thigh of rabbits. Four days later 131I-ORN was intravenously administered to rabbits. Serial scintigrams were performed at different periods, using a Sophy DX Gamma Camera. 131I-ORN was visualized at 10 min after injection. 131I-ORN was also administered intraperitoneally to rats with turpentine-induced inflammation, for quantitative biodistribution studies. Counts of selected tissues were taken by a NaI(Tl) scintillation detector (gamma counter) after rats were decapitated. The target-to-non-target muscle ratios were 2.5, 2.6, 2.9 and 1.9 at 1, 3, 5 and 24 h, respectively. Copyright (C) 2000 Elsevier Science Ltd.en10.1016/S0969-8043(99)00150-5info:eu-repo/semantics/closedAccessArticle53341141310972145Q3