Ichedef, CigdemTeksoz, SerapSenocak, KamileUcar, EserKilcar, Ayfer Yurt2019-10-272019-10-2720110236-57310236-5731https://doi.org/10.1007/s10967-011-1164-1https://hdl.handle.net/11454/46120The aim of this study is to prepare radiolabeled guanine with Tc-99m(CO) (3) (+) core. For this purpose, guanine has been radiolabeled with Tc-99m(CO) (3) (+) core. Quality control study of radiolabeled guanine molecule with Tc-99m(CO) (3) (+) core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The results showed that the radiolabeling yield was quite high (94 +/- A 3%). Beside that Tc-99m(CO)(3)-Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was evaluated in Wistar Albino Rats. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for in vivo applications.en10.1007/s10967-011-1164-1info:eu-repo/semantics/closedAccessGuanineTc-99m(CO)(3)(+)RadiolabelingBiodistributionArticle2893845849WOS:000293029200025Q1