Kalyoncu, TugbaOzbaran, BurcuKose, SezenOnay, Huseyin2019-10-272019-10-2720191087-05471557-12461087-05471557-1246https://doi.org/10.1177/1087054717706757https://hdl.handle.net/11454/29032Objective: Children with ADHD show substantial deficits in social cognitive abilities. Oxytocin, mediated through its specific receptor (OXTR), is involved in the regulation of social behavior and social cognition. Method: The entire coding sequence of the human OXT and OXTR genes were sequenced to identify mutations and single nucleotide polymorphisms (SNPs) in 151 children with ADHD (ADHD-combined, n = 51; inattentive subtype, n = 50; ADHD-C plus conduct disorder [CD], n = 50; 11-18 years) and 100 healthy controls. Results: We examined the association of three detected SNPs of OXTR with social cognition deficits. A significant association was shown between the children with ADHD and children with CT/TT genotypes of rs4686302 (chi(2) = 3.695; p = .037). ADHD children with CT/TT genotype for the OXTR rs4686302 performed significantly lower on the facial emotion recognition task than those with CC genotype. Conclusion: OXTR rs4686302 polymorphism was shown to be a genetic marker in social cognition deficits in ADHD children.en10.1177/1087054717706757info:eu-repo/semantics/openAccesssocial cognitionoxytocin geneoxytocin receptor genepolymorphismADHD subtypesArticle237702711WOS:000465015800006Q1Q1