Unak P.Enginar H.Zümrüt Biber F.Yurt Lambrecht F.Aslani M.A.A.Ozkilic H.2019-10-272019-10-2720020969-8043https://doi.org/10.1016/S0969-8043(02)00190-2https://hdl.handle.net/11454/27937Tissue distribution of the 99mTc labeled derivative of the estrogen compound 3,17-?-estradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid) ester (ESTCPTA), which has an 3,17-?-estradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA), was compared to 99mTc-MIBI (methoxyisobutyl isonitrile) in female Albino Wistar rats. Tissues of interest included lung, liver, heart, kidneys, spleen, stomach, intestines, pancreas, muscle, blood, breast, ovary, fat, and uterus. 99mTc-ESTCPTA uptake by the uterus and ovary, as ER-rich tissues, was highly selective. Maximum uptakes for 99mTc-MIBI and 99mTc-ESTCPTA are 90min in breast, ovary and uterus. The pancreas also showed significant receptor saturated and unsaturated ratios for 99mTc-ESTCPTA. Results are sufficiently encouraging to generate further evaluation of these and related compounds as possible estrogen receptor based tumor imaging and therapeutic agents in estrogen-rich tissues. © 2002 Published by Elsevier Science Ltd.en10.1016/S0969-8043(02)00190-2info:eu-repo/semantics/closedAccessEREstrogen derivativesEstrogen receptorEthynyl estradiolRatTc-99m labeled ESTCPTATc-99m labeled MIBIArticle57573374212433049Q3