Simsek, SerifeCanter, Halil IbrahimKonas, ErsoyKorkusuz, PetekDemir, DevrimOner, FilizUnsal, IbrahimMavili, Mehmet Emin2019-10-272019-10-2720110148-7043https://doi.org/10.1097/SAP.0b013e31822af865https://hdl.handle.net/11454/45838Objective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. Material and Methods: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer. Results: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed. Conclusion: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.en10.1097/SAP.0b013e31822af865info:eu-repo/semantics/closedAccesscontrolled slow-releaseGM-CSFchitosanburnArticle676583588WOS:00029808590001522123539Q3