Tarikogullari A.H.Kilic F.S.Erol K.Pabuccuoglu V.2019-10-262019-10-2620100004-4172https://hdl.handle.net/11454/19653A group of N -phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at ? position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(2,6-dimethylphenyl)acetamide. © ECV · Editio Cantor Verlag.eninfo:eu-repo/semantics/closedAccessAlkanamideAnilideAnticonvulsant drugsImidazolePyrazoleTriazoleArticle601059359821125808N/A