Karadeniz H.Armagan G.Erdem A.Turunc E.Caliskan A.Kanit L.Yalcin A.2019-10-272019-10-2720091040-03971040-0397https://doi.org/10.1002/elan.200900218https://hdl.handle.net/11454/27214A possible DNA damage after interaction of kainic acid (KA) with calf thymus double stranded DNA and genomic DNA was herein determined in in vitro and in vivo conditions using; electrochemical assay and agarose gel electrophoresis. The changes in guanine signal were detected as an indicator of DNA damage in genomic DNA samples isolated from 1 or 10 mg/kg KA-treated animals. The decreased levels of guanine signal were found as 29% and 33% by 1 and 10 mg/kg KA treatment when compared to controls, respectively. The results of gel electrophoresis confirmed DNA damage obtained in identical samples by electrochemical method.© 2009 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.en10.1002/elan.200900218info:eu-repo/semantics/closedAccessAgarose gel electrophoresisDna damageElectrochemical sensor technologyElectrophoresisGuanine signalKainic acidArticle212224682476Q2