Moharrami, PayamUnak, PerihanGuldu, Ozge KozgusMedine, E. I.Gumuser, GulBilgin, Elvan SayitAras, Omer2019-10-272019-10-2720170236-57311588-27800236-57311588-2780https://doi.org/10.1007/s10967-017-5630-2https://hdl.handle.net/11454/31454A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with Tc-99m which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of Tc-99m-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that Tc-99m-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.en10.1007/s10967-017-5630-2info:eu-repo/semantics/closedAccessDiethylstilbestrolQuantum dot nanoparticlesCancer imagingBreast cancerProstate cancerLung cancerArticle314326092620WOS:000416545300117Q2