Kayce, PeykerKirmizigul, Suheyla2019-10-272019-10-2720171478-64191478-6427https://doi.org/10.1080/14786419.2016.1212029https://hdl.handle.net/11454/33141A new hederagenin-type triterpenoid glycoside (1) named Aytachoside A, along with eight known triterpene glycosides, were isolated from the aerial parts of Cephalaria aytachii Gokturk and Sumbul (Dipsacaceae). The structures of compounds 1-9 were determined by spectroscopic (1D and 2D NMR, HRESIMS) and chemical examinations. The antimicrobial effect of compound 1 was found considerably active against Escherichia coli, Pseudomonas aeruginosa and especially Salmonella typhimurium microorganisms using the MIC method. Although compound 1 was found not to have a remarkable toxic effect at a concentration lower than 300g/mL, cytotoxic activity tests demonstrated that prosapogenin 1a exhibits a significant cytotoxic activity against HeLa cell lines using the MTT assay for the first time.en10.1080/14786419.2016.1212029info:eu-repo/semantics/closedAccessAytachoside ADipsacaceaeCephalaria aytachiitriterpene saponinantimicrobial activitycytotoxic activityArticle3115057WOS:00038897080000827454791Q2Q2