Gokcek, Ozden CanbayOzkeskin, MehmetBaser, Miray2024-08-312024-08-3120241309-3878https://doi.org/10.18521/ktd.1356975https://search.trdizin.gov.tr/tr/yayin/detay/1246571https://hdl.handle.net/11454/104160Objective: Systemic lupus erythematosus (SLE) is a multisystem chronic autoimmune disease characterized by recurrent and relapsing attacks that may affect the locomotor system as well as the liver and kidneys. Vitamin D deficiency is thought to playAa role in the pathogenesis of SLE. ATherefore, the primary aim of this literature review is to determine the role of vitamin D deficiency on SLE symptoms. The secondary aim is to explain the benefits of exercise on SLE-related comorbidities. Methods: A comprehensive literature search on SLE symptoms, biochemistry, and pathophysiology was conducted via Google Scholar. The impact of exercise on comorbidities associated with SLE was examined. Results: The precise etiology of the disease remains elusive, although there is mounting evidence that vitamin D deficiency is associated with symptoms of SLE. In addition to pharmacological treatment for the involvement of the locomotor system in SLE patients, physiotherapy applications are also included. This review presents evidence of the positive effects of exercise on pain, fatigue, and sleep problems caused by disease-related or side effects of pharmacological applications used in the treatment of SLE patients. Conclusions: It is not possible to correct the symptoms of SLE associated with vitamin D deficiency by means of vitamin D supplementation alone. At this juncture, it is hypothesized that exercise may offer potential benefits in correcting vitamin D deficiency. AConsequently, exercise exerts a beneficial influence on the comorbidities associated with SLE. AFuture studies should be planned to establish an appropriate exercise prescription for SLE.en10.18521/ktd.1356975info:eu-repo/semantics/openAccessSystemic Lupus ErythematosusExerciseFatiguePainSleep DisordersVitamin DReview Article1621992041246571WOS:001272220200009N/A