Aksoy, Semiha CetinelUzel, AtacBedir, Erdal2019-10-272019-10-2720160021-8820https://doi.org/10.1038/ja.2015.72https://hdl.handle.net/11454/51532Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional (H-1 and C-13) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.en10.1038/ja.2015.72info:eu-repo/semantics/closedAccessArticle6915156WOS:00037067680000726126744Q2Q2