Gokce, GokselKaravana, Sinem YaprakBagriyanik, AlperPekcetin, CetinAlgin Yapar, EvrenAybar Tural, GulsenGokce, Evren Homan2023-01-122023-01-1220221300-01521303-6092https://doi.org/10.55730/1300-0152.2612https://search.trdizin.gov.tr/yayin/detay/532203https://hdl.handle.net/11454/79007Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by oxidative stress.en10.55730/1300-0152.2612info:eu-repo/semantics/openAccessTaurineantioxidantbio-adhesive gelburn wound modelMucoadhesiveTaurineMelatoninChitosanArticle463251262532203WOS:0008151692000062-s2.0-85134539321Q2Q3