Simsir, Ilgm YildirimSoyaltin, Utku ErdemYurekli, Banu SarerErdogan, MehmetCetinicalp, SevkiSaygili, FusunDonmez, AyhanOzgen, Ahmet Gokhan2019-10-272019-10-2720191300-01441303-6165https://doi.org/10.3906/sag-1811-105https://hdl.handle.net/11454/29457Background/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined. Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center. Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 2-2, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 +/- 1472 mg/dL) than the mean TG level afterwards (948 +/- 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE. Conclusion: TPE is a safe, fast, and effective treatment modality in experienced centers.en10.3906/sag-1811-105info:eu-repo/semantics/openAccessHypertriglyceridemiapancreatitisapheresistherapeutic plasma exchangefresh frozen plasmaArticle493872878WOS:00047190220002531203594Q3Q4