Ciftdogan, Dilek YilmazOnay, HuseyinTosun, SelamOzdemir, Taha ResidÖzkınay, FerdaVardar, Fadil2019-10-272019-10-2720141746-07941746-08081746-07941746-0808https://doi.org/10.2217/fvl.13.124https://hdl.handle.net/11454/48365Aim: We investigated the +874 T/A polymorphism in the first intron of the IFNG gene and intronic (CA)(n) polymorphic microsatellite marker of the IFNGR1 gene in child nonresponders to hepatitisB vaccination. Materials & methods: A total of 100 children who had anti-HBs antibody levels <10 mIU/ml after vaccination against hepatitisB were included as a nonresponder group and 100 children who had anti-HBs antibody levels >10mIU/ml after vaccination against hepatitisB were included as a responder group. Results: The frequency of the TT genotype of the IFNG (+874 T/A) gene polymorphism was higher in nonresponders (p = 0.003). The frequencies of alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of IFNGR1 were significantly higher in nonresponders (for each, p<0.05). Conclusion: The TT genotype of the IFNG (+874 T/A) gene, and alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of the IFNGR1 gene, may be associated with nonresponse to hepatitisB vaccination.en10.2217/fvl.13.124info:eu-repo/semantics/closedAccesschildgene polymorphismhepatitisBIFN-interferon gammavaccineArticle92123130WOS:000332088000007Q4Q4