Al-Jibori S.A.Al-Jibori G.H.Al-Hayaly L.J.Wagner C.Schmidt H.Timur S.Barlas F.B.Subasi E.Ghosh S.Hogarth G.2019-10-272019-10-2720140162-0134https://doi.org/10.1016/j.jinorgbio.2014.07.017https://hdl.handle.net/11454/26337The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. © 2014 Elsevier B.V. All rights reserved.en10.1016/j.jinorgbio.2014.07.017info:eu-repo/semantics/closedAccessAmmineAnti-cancerCisplatinSaccharinateThiosaccharinateX-ray structureArticle1411555725216367Q1