Enginar H.Unak P.Lambrecht F.Y.Biber F.Z.Medine E.I.Cetinkaya B.2019-10-272019-10-2720050236-57310236-5731https://doi.org/10.1007/s10967-005-0749-yhttps://hdl.handle.net/11454/27766The aim of this study is to synthesize novel 131I labeled estrone derivatives that may have therapeutical potentials on Estrogen Receptor rich tumors. Two radiolabeled estrone derivatives, [131I]2-iodo-3- methoxy-estra-1,3,5-trien-17-one and [131I]4-iodo-3-methoxy-estra-1, 3,5-trien-17-one were synthesized. Ether amino estrone derivatives were obtained from estrone in three steps by means of diazonium compounds. Tissue distribution studies exhibited receptor-mediated uptake in target organs in female Albino Wistar rats. Maximum uptakes for 2-iodo[131I]-3- methoxy-estrone are in stomach, pancreas, intestines and uterus. A similar biodistribution profile was obtained for 4-iodo[131I]-3-methoxy- estrone. However 2-iodo-3-methoxy-estra-1,3,5-trien-17-one has higher uptake in stomach, kidneys, pancreas, and intestines than 4-iodo-derivative. © 2005 Akadémiai Kiadó.en10.1007/s10967-005-0749-yinfo:eu-repo/semantics/closedAccessArticle2643535539Q2